Peptide-Loaded Solid Lipid Nanoparticles Prepared through Coacervation Technique

Peptide-Loaded Solid Lipid Nanoparticles Prepared through Coacervation Technique

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Stearic acid solid lipid nanoparticles were prepared according to a new technique, called coacervation.The main goal of this experimental work Brake Shoes was the entrapment of peptide drugs into SLN, which is a difficult task, since their chemical characteristics (molecular weight, hydrophilicity, and stability) hamper peptide-containing formulations.Insulin and leuprolide, chosen as model peptide drugs, were Rugby - Accessories encapsulated within nanoparticles after hydrophobic ion pairing with anionic surfactants.Peptide integrity was maintained after encapsulation, and nanoparticles can act in vitro as a sustained release system for peptide.